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(2007) observed that pineal gland peptides, including epithalon, work to enhance antioxidant response in research subjects

It has been shown that, during chemotherapy, tumor cells could overcome drug-induced OS by enhancing their antioxidant systems as well as an increasing P-gp pump efflux to acquire a new redox balance due the increased ROS accumulation and antioxidant systems in a process of redox rearranging (see Figure 1)

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In addition to direct screening, engineering wild-type NAMPT is considered essential for increasing its enzymatic activity ( Huang et al., 2022 )

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